5 ms·
Would you actually want drug research to _not_ be regulated?
by orbat 10y ago
Would you actually want drug research to _not_ be regulated?
- fivesigma 10y agoI want drug research (and approval) to _not_ cost billions of dollars per drug just to justify the salary of a few bureaucrats.
- ekianjo 10y agoNot only it's expensive, but tons of existing drugs have been approved with loose standards (a single trial showing better efficacy than placebo, wow, big deal!). Every new drug should be benchmarked against the best drug in class, and period. Instead of that you end up with doctors who have no idea which drugs work the best and who rely on companies to "educate" them, with obvious conflict of interest.
- jonlucc 10y agoThat is the current standard (Ph 3 clinical trials against standard of care). There are rare exceptions to this, but the ones I can think of are drugs for which there is no current standard and drugs for which the current standard doesn't match the intended indication. In modern medicine, we don't just take diagnosed patients who meet criteria for a trial and let them progress without disease.
- ekianjo 10y agoThats why I mentioned "have been". But such drugs are still being sold.patented and used.
- jonlucc 10y agoYes; our system makes it very difficult to put horses back in the barn. I heard one physician say that Tylenol would not make it through today, or at the very least it would be prescription, because of the slim toxicity margin.
- Retric 10y agoTylenol causes ~56,000 emergency room visits, 2,600 hospitalizations, and ~450 deaths per year. IMO, at a minimum it should have much stronger warning labels on it.
- hohenheim 10y agoOut of curiosity, is there any reference that breaks down the costs of approval process? Like how much goes to fees in trial, staff, etc.
- replicatorblog 10y ago"Best" is rarely a clear cut answers. There is pretty wide variation in the several billion people on the planet. Some have serious side effects, others have none. Some drugs work well as part of a cocktail, but not as stand alones. This idea of selecting a single best option and making everything relative to it would have a strong adverse impact on the market. It would be like saying we shouldn't clear a Ferrari when a Corolla can get groceries just fine at a lower cost.
- deleted 10y ago[deleted]
- ahartman00 10y agoYou think the drug approval process is only to justify the salaries of a few bureaucrats? there is no other reason? safety doesnt factor in at all? I must be misunderstanding you here