Python is wonderful for business logic and scientific computations. HTML/JavaScript is wonderful to make beautiful interactive user interfaces. So at the momen

Python is wonderful for business logic and scientific computations. HTML/JavaScript is wonderful to make beautiful interactive user interfaces. So at the moment, I am using PyQt/PySide and load my HTML/JavaScript/ReactJS GUI in a webview with a simple bridge object between my Python code and the JavaScript code. As soon as I need native interactions with the file system, etc., I am using Python, which is robust and proven (and I am used to it). For example, if I need a dialog to save a file, I just use QFileDialog. At the end, because of a clear separation between the GUI and the computation/system interactions with the bridge object, I just need a different bridge object to have everything running fully online. One point is of course that I am not developing for phones and tablets, I package everything with pyinstaller for the good old desktop users.