4 ms·

> If you think about it, any molecule that isn't sugar but tastes like sugar will have a similar molecular shape to sugar. I'm going to go out on a limb here a

by apathy 10y ago

> If you think about it, any molecule that isn't sugar but tastes like sugar will have a similar molecular shape to sugar. I'm going to go out on a limb here and propose that you may not be a professional medicinal chemist. Many theories conveniently support your position. Of course, many theories conveniently support the other side. How can we objectively determine who is right? Well, let's look at (among many, many other experimental studies) http://www.ncbi.nlm.nih.gov/pubmed/25786106 http://www.ncbi.nlm.nih.gov/pubmed/25786106 which is a recent study of metabolic differences between self-reported aspartame sensitive and non-sensitive individuals. Double-blind, randomised crossover study -- the gold standard. Any differences in metabolic profile between either control/aspartame or sensitive/not? None seen. However, perhaps all non-nutritive sweeteners are not alike. The same senior author as above ran a separate study in a small sample of athletic males where aspartame in addition to carbohydrates resulted in lower insulin response during exercise: https://jissn.biomedcentral.com/articles/10.1186/1550-2783-9-36 https://jissn.biomedcentral.com/articles/10.1186/1550-2783-9... Meanwhile, and in a different (grossly obese, NNS-naive) population, sucralose (Stevia) appeared to do the opposite: http://care.diabetesjournals.org/content/early/2013/04/30/dc12-2221 http://care.diabetesjournals.org/content/early/2013/04/30/dc... > Many of these questions can be answered without slow, hard science Sure, if we don't care whether the answers are credible. Proof by analogy is fraud. If we didn't need evidence to make decisions we wouldn't bother accumulating it.

buu700 10y ago
> sucralose (Stevia) s/Stevia/Splenda/ (stevia is entirely different from sucralose).
- apathy 10y ago
  Oh wow I fucked that one up. Thank you for correcting it.
  - luketych 10y ago
    You are easy to read. You admit a small error so that you can feel justified on your larger point. Hard to explain, but it is like reading the body language of a younglin. Sometimes you even know what they are thinking before they do.
    - apathy 10y ago
      Your central thesis -- molecules that taste like sugar have the same shape -- is unalloyed horseshit. Pull up the structures for glucose and aspartame. Are you seriously claiming they are similar? Incidentally, I'm probably old enough to be your father, unless you're in a nursing home.
      - luketych 10y ago
        "Your central thesis -- molecules that taste like sugar have the same shape -- is unalloyed horseshit." Wow you are so smart! Yay!!! You use big boy terms like "central thesis." Congratulations, your brain has the ability of language. You must be pretty slow. Again, you are displaying your own lack of awareness to the whole world. Enjoy your upvotes because the majority of these readers are even less aware than you. But I am sure you feel good knowing that you have the majority on your side :). Awwwwww, how cute. Why don't you tell me how sweetness works genius, or do you not know what a receptor is? Just because glucose and aspartame don't look the same doesn't mean they can't work the same. I am amazed by your lack of understanding, and you are braggin' that you are how old?... I bet you are the type of person who always looks for the difference in things, rather than the similarities. I bet you can't even tell in what ways one song or piece of art draws inspiration from another. That involved a lot of divergent thinking (and convergent, etc.), but I see that you do not have that ability. Sorry there budd. Haha. Successfully mindfucked. I will admit that I planned on getting you to react in a certain way and you did. Enjoy your votes, Darsh.
      - luketych 10y ago
        My final thought before I leave you is that you are likely emotionally vested in this issue and so your limbic system is blinding your neo-cortex. Perhaps you or someone you care for deeply uses artificial sweeteners. Maybe you are pedantic and are passionate about proving things to 100% (is that even possible?). I am not sure. But for a rational mind, you are very emotional as well. Maybe you see yourself as a free mind who will sort the wheat from the chaff in order to destroy false information and flawed science. When I was younger I would care about someone like yourself. Now, honestly I don't give af. You are for training on. Nothing more. Soak it up before comments get deleted. IF they do..
luketych 10y ago
LMAO. Did I say that analogy is the end of the road? You are one entertaining dude.

by apathy 10y ago

buu700 10y ago

> sucralose (Stevia) s/Stevia/Splenda/ (stevia is entirely different from sucralose).

apathy 10y ago
Oh wow I fucked that one up. Thank you for correcting it.
- luketych 10y ago
  You are easy to read. You admit a small error so that you can feel justified on your larger point. Hard to explain, but it is like reading the body language of a younglin. Sometimes you even know what they are thinking before they do.
  - apathy 10y ago
    Your central thesis -- molecules that taste like sugar have the same shape -- is unalloyed horseshit. Pull up the structures for glucose and aspartame. Are you seriously claiming they are similar? Incidentally, I'm probably old enough to be your father, unless you're in a nursing home.
    - luketych 10y ago
      "Your central thesis -- molecules that taste like sugar have the same shape -- is unalloyed horseshit." Wow you are so smart! Yay!!! You use big boy terms like "central thesis." Congratulations, your brain has the ability of language. You must be pretty slow. Again, you are displaying your own lack of awareness to the whole world. Enjoy your upvotes because the majority of these readers are even less aware than you. But I am sure you feel good knowing that you have the majority on your side :). Awwwwww, how cute. Why don't you tell me how sweetness works genius, or do you not know what a receptor is? Just because glucose and aspartame don't look the same doesn't mean they can't work the same. I am amazed by your lack of understanding, and you are braggin' that you are how old?... I bet you are the type of person who always looks for the difference in things, rather than the similarities. I bet you can't even tell in what ways one song or piece of art draws inspiration from another. That involved a lot of divergent thinking (and convergent, etc.), but I see that you do not have that ability. Sorry there budd. Haha. Successfully mindfucked. I will admit that I planned on getting you to react in a certain way and you did. Enjoy your votes, Darsh.
    - luketych 10y ago
      My final thought before I leave you is that you are likely emotionally vested in this issue and so your limbic system is blinding your neo-cortex. Perhaps you or someone you care for deeply uses artificial sweeteners. Maybe you are pedantic and are passionate about proving things to 100% (is that even possible?). I am not sure. But for a rational mind, you are very emotional as well. Maybe you see yourself as a free mind who will sort the wheat from the chaff in order to destroy false information and flawed science. When I was younger I would care about someone like yourself. Now, honestly I don't give af. You are for training on. Nothing more. Soak it up before comments get deleted. IF they do..

luketych 10y ago

LMAO. Did I say that analogy is the end of the road? You are one entertaining dude.