4 ms·
Thanks to blue1 who found the original paper (http://www.cell.com/cell-stem-cell/fulltext/S1934-5909%2814%2900151-9 http://www.cell.com/cell-stem-cell/fulltext/
by xarope 10y ago
Thanks to blue1 who found the original paper (http://www.cell.com/cell-stem-cell/fulltext/S1934-5909%2814%2900151-9 http://www.cell.com/cell-stem-cell/fulltext/S1934-5909%2814%...), I found this in the comments section: "In this study, the mice were allowed to drink water, but no food was allowed. In general, when limited food & water are allowed, the protocol is referred to as a "fasting-mimicking diet""
So no food, but water was allowed.
Just remember the context: the mice were subjected to chemotherapy schedules... so it's not like "hey take healthy mice, fast them and see them get healthy", but more like "hey take healthy mice, fast them, subject them to chemotherapy, and look... their immune system responds better than if we allowed them to eat pre-chemo" (apologies if I summarised this wrong)
- davidwparker 10y agoThat paper isn't the original- it's a followup. The original is a strict fast (water only) for 72 hours. The FMD (Fasting Mimic Diet) is for 120 hours (5 days) and has more food allowed: "The human FMD diet consists of a 5 day regimen: day 1 of the diet supplies 1,090 kcal (10% protein, 56% fat, 34% carbohydrate), days 2–5 are identical in formulation and provide 725 kcal (9% protein, 44% fat, 47% carbohydrate)."
- AstralStorm 10y agoWow, that's lower than what many calorie restriction experimenters run!
- davidwparker 10y agoYeah, it's supposed to "Mimic" a fast. Supposedly it's easier to do than the 3-day water only fast, since you're getting some sustenance, but I haven't tried it.