It's done with Node.js and nginx all the time. Other than the initial configuration nginx is essentially stateless, and there's simple setups out there to autom

It's done with Node.js and nginx all the time. Other than the initial configuration nginx is essentially stateless, and there's simple setups out there to automate the nginx config as well, with docker for example: https://github.com/jwilder/nginx-proxy https://github.com/jwilder/nginx-proxy.