3 ms·

The theory is sound [1], but as in many situations with a lot of different actors, you get some coordination problems. Already many countries have some rules ab

The theory is sound [1], but as in many situations with a lot of different actors, you get some coordination problems. Already many countries have some rules about how and when you can use certain anti-biotics, and some countries completely ignore them, or ignore them when it's profitable (farmers, usually, from what I gather.[2]) Even given the variety of anti-biotics we have now, if they were on a kind of 4 or 5 year rotation schedule that was actually followed, given the reproductive rate of bacteria i suspect that would work anyways, so hoping for coordination would certainly help, a solution that wouldn't require humans being more cooperative would be greatly expanding the diversity of our anti-biotics. [1] http://science.howstuffworks.com/life/cellular-microscopic/drug-resistant-bacteria-lose-resistance.htm http://science.howstuffworks.com/life/cellular-microscopic/d... [2] https://www.youtube.com/watch?v=xZbcwi7SfZE https://www.youtube.com/watch?v=xZbcwi7SfZE

ethbro 10y ago
Out of curiosity, is there a reason antibiotic cocktails aren't used more often? Cost? Seems like it would be more productive and play to human nature if we could decrease the cost of cocktails and mandate that they're always used instead of singular antibiotics.
- wolfram74 10y ago
  When considering the axis of creating super bugs, cocktails would probably exacerbate the problem, since now you're applying several stressors in parallel. Unless you had like, 5 or so fundamentally different avenues of attack, then you could get, what, 30~ unique combos? Most people don't need anti-biotics more than 10 times in their life? If it they were equally valid in any case, doctors could just choose randomly from the set of cocktails they haven't used on a given patient before. I'm certain a cell biologist would tell me this is a dumb plan for some reason, though.
- maxerickson 10y ago
  I think a big part of it is that single antibiotics have been quite effective. So there isn't a developed practice of using cocktails and the interactions and so on aren't necessarily well tested/understood. The most recent course of antibiotics I took was a combination of antibiotics though, so it's changing. https://en.wikipedia.org/wiki/Amoxicillin/clavulanic_acid https://en.wikipedia.org/wiki/Amoxicillin/clavulanic_acid

ethbro 10y ago

Out of curiosity, is there a reason antibiotic cocktails aren't used more often? Cost? Seems like it would be more productive and play to human nature if we could decrease the cost of cocktails and mandate that they're always used instead of singular antibiotics.

wolfram74 10y ago
When considering the axis of creating super bugs, cocktails would probably exacerbate the problem, since now you're applying several stressors in parallel. Unless you had like, 5 or so fundamentally different avenues of attack, then you could get, what, 30~ unique combos? Most people don't need anti-biotics more than 10 times in their life? If it they were equally valid in any case, doctors could just choose randomly from the set of cocktails they haven't used on a given patient before. I'm certain a cell biologist would tell me this is a dumb plan for some reason, though.
maxerickson 10y ago
I think a big part of it is that single antibiotics have been quite effective. So there isn't a developed practice of using cocktails and the interactions and so on aren't necessarily well tested/understood. The most recent course of antibiotics I took was a combination of antibiotics though, so it's changing. https://en.wikipedia.org/wiki/Amoxicillin/clavulanic_acid https://en.wikipedia.org/wiki/Amoxicillin/clavulanic_acid