Anecdote: I had a far-too-large dose produce obvious precipitated withdrawal – intense sneezing, elevated body temperature, and nausea. It resolved in a few hou

Anecdote: I had a far-too-large dose produce obvious precipitated withdrawal – intense sneezing, elevated body temperature, and nausea. It resolved in a few hours. The plant contains a mix of agonists and antagonists IIRC, and this seemed to be protective. I don't use the stuff anymore, but it certainly didn't ruin (or even really damage) my life.