Its not really a single rule rather a combination of more regulations for botanical mixtures and difficulties with patents such that drug companies always prefe

Its not really a single rule rather a combination of more regulations for botanical mixtures and difficulties with patents such that drug companies always prefer to isolate and market molecules rather than mixtures. The idea is to know and control everything about the drug. In cases like this and basically all opiates that's clearly a dumb policy since concentrating the active ingredient promotes abuse and probably eliminates the other ingredients which induce the nausea that prevents abuse and makes kratom safe :/ Few died in the opium dens of the past. Today opiate addiction gives you a decent chance of dying in an od and its due to this policy. https://www.google.com/url?sa=t&source=web&rct=j&url=http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm070491.pdf&ved=0ahUKEwj2tv6u4_DOAhVExGMKHUY-BIwQFggbMAA&usg=AFQjCNGVbbTzd_lBIUgbUTh3x3K4ADuuYw https://www.google.com/url?sa=t&source=web&rct=j&url=http://...