If your threat model now includes 'the attacker can at arbitrary times make arbitrary alterations to the working memory of my process' then no, this won't help.

If your threat model now includes 'the attacker can at arbitrary times make arbitrary alterations to the working memory of my process' then no, this won't help. You can't trust the checksum, you can't trust that the data you just check summed hasn't subsequently changed, and you can't trust that data which passes a checksum wasn't previously different. Also you can't trust the checksum code itself. Or the operating system you're running on. Or anything.