3 ms·

Whoops... "there are abundant opportunities for error, particularly when you are relying on software to do much of the work. This was made glaringly ap

Whoops... "there are abundant opportunities for error, particularly when you are relying on software to do much of the work. This was made glaringly apparent back in 2009, when a graduate student conducted an fM.R.I. scan of a dead salmon and found neural activity in its brain when it was shown photographs of humans in social situations. Again, it was a salmon. And it was dead."

frozenport 10y ago
The dead Salmon was taught in one of our classes in 2010, and still nobody gives a fuck, they just fMRI on. Its not a software bug, its a people bug.
S_Daedalus 10y ago
We go through this with each new tech, such as with EEG and Jello.
ChuckMcM 10y ago
I read a great (in the sense that it was laugh out loud preposterous) paper that used this experiment to assert that re-incarnation was a thing, as the salmon, post mortem, had been re-incarnated as a person but not yet born, their portal to the soul was now interpreting pictures as if the fish were both human and alive. It was a tour de force in circular reasoning. It may have been in the Journal of Irreproducible Results. One way to read scientific papers is to deconstruct the apparatus in the experiment to see if it could actually produce the data in the paper, and if so, what would have to be true for it to do so. Good papers go through that in experimental design section, bad papers gloss over it or toss it out as a stipulation "We used the same instrument that everyone else uses to read brain activity the fMRI scanner." (bad) "We used a technique called fMRI scanning which measures the magnetic resonance of hemoglobin in the blood, specifically it measures the difference between oxygen rich and oxygen poor hemoglobin." (much better) Then as a reader you can see that any change in oxygen, whether it is brain activity or bacterial decomposition would show up in such a resonance scan.
- kobayashi 10y ago
  Would love to see that paper!
  - wutangson1 10y ago
    Downvote me all you like, but it has to be said that Kobayashi is responding to McManis :0
    - kobayashi 10y ago
      lol, great notice!
mattkrause 10y ago
This is actually a somewhat different issue. The salmon "result" is essentially a multiple comparisons problem. In a typical fMRI analysis, the researchers run a huge number of significance tests, one per voxel (i.e., 3d pixel). Even if false positives are relatively rare on a per-test basis, you're going to see a non-trivial amount of them when you run a large number of tests. This phenomenon was well-known in the statistical literature...and in the fMRI literature, but sometimes it takes a cute little parable, like the salmon, to drive something home. In this case, however, there was one honest-to-God bug (in AFNI). The other software modeled something in a way that sounds fairly reasonable, but didn't quite line up with the way that nature (or, actually, the scanner manufacturers) behaved. Unlike the fish issue, I think you could legitimately try to do things correctly and still get bit by this sort of bug.
Kliment 10y ago
Link to salmon study: http://prefrontal.org/files/posters/Bennett-Salmon-2009.pdf http://prefrontal.org/files/posters/Bennett-Salmon-2009.pdf Choice quotes: "[the salmon] was not alive at the time of scanning" "The salmon was asked to determine what emotion the individual in the photo must have been experiencing."
DanBC 10y ago
Please don't put leading spaces in front of quotes. You fuck the formatting for mobile users.

frozenport 10y ago

The dead Salmon was taught in one of our classes in 2010, and still nobody gives a fuck, they just fMRI on. Its not a software bug, its a people bug.

S_Daedalus 10y ago

We go through this with each new tech, such as with EEG and Jello.

ChuckMcM 10y ago

I read a great (in the sense that it was laugh out loud preposterous) paper that used this experiment to assert that re-incarnation was a thing, as the salmon, post mortem, had been re-incarnated as a person but not yet born, their portal to the soul was now interpreting pictures as if the fish were both human and alive. It was a tour de force in circular reasoning. It may have been in the Journal of Irreproducible Results. One way to read scientific papers is to deconstruct the apparatus in the experiment to see if it could actually produce the data in the paper, and if so, what would have to be true for it to do so. Good papers go through that in experimental design section, bad papers gloss over it or toss it out as a stipulation "We used the same instrument that everyone else uses to read brain activity the fMRI scanner." (bad) "We used a technique called fMRI scanning which measures the magnetic resonance of hemoglobin in the blood, specifically it measures the difference between oxygen rich and oxygen poor hemoglobin." (much better) Then as a reader you can see that any change in oxygen, whether it is brain activity or bacterial decomposition would show up in such a resonance scan.

kobayashi 10y ago
Would love to see that paper!
- wutangson1 10y ago
  Downvote me all you like, but it has to be said that Kobayashi is responding to McManis :0
  - kobayashi 10y ago
    lol, great notice!

mattkrause 10y ago

This is actually a somewhat different issue. The salmon "result" is essentially a multiple comparisons problem. In a typical fMRI analysis, the researchers run a huge number of significance tests, one per voxel (i.e., 3d pixel). Even if false positives are relatively rare on a per-test basis, you're going to see a non-trivial amount of them when you run a large number of tests. This phenomenon was well-known in the statistical literature...and in the fMRI literature, but sometimes it takes a cute little parable, like the salmon, to drive something home. In this case, however, there was one honest-to-God bug (in AFNI). The other software modeled something in a way that sounds fairly reasonable, but didn't quite line up with the way that nature (or, actually, the scanner manufacturers) behaved. Unlike the fish issue, I think you could legitimately try to do things correctly and still get bit by this sort of bug.

Kliment 10y ago

Link to salmon study: http://prefrontal.org/files/posters/Bennett-Salmon-2009.pdf http://prefrontal.org/files/posters/Bennett-Salmon-2009.pdf Choice quotes: "[the salmon] was not alive at the time of scanning" "The salmon was asked to determine what emotion the individual in the photo must have been experiencing."

DanBC 10y ago

Please don't put leading spaces in front of quotes. You fuck the formatting for mobile users.