Oh this happens constantly. Apparently, in an ideal world, every gene will have multiple counterintuitive symbols that appear to give insight as to what the pr

Oh this happens constantly. Apparently, in an ideal world, every gene will have multiple counterintuitive symbols that appear to give insight as to what the protein does, but are in fact misleading. HGNC seems to delight in nonsensical renaming. MLL (Mixed-lineage leukemia, a gene rearranged in many leukemias, particularly infants) is now KMT2A ("Lysine Methyl-Transferase 2A"), yet gobs of its fusion partners are canonically named, say, MLLT3 ("Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 3"). But wait, what's its translocation partner? Oh, right, the Gene Formerly Known As MLL. Who thinks this is a good idea? Journals typically insist on the latest HGNC (HUGO Gene Nomenclature Committee, a subset of the HUman Genome Organization) symbols, whatever they might be (see above). Not atypically, in review, someone will ask to use the old name because that's what they're used to. Best of all is when reviewers each suggest using a different name. Science!