"After a rocky start — in his memoir, Ageless Quest, Guarente cops to quitting smoking when he was in third grade — he has lived a generally healthy life. Besid

"After a rocky start — in his memoir, Ageless Quest, Guarente cops to quitting smoking when he was in third grade — he has lived a generally healthy life. Besides Basis, he takes a low-dose statin, aspirin, and vitamin D; weighs himself every day; eats a mostly Mediterranean diet (red wine included); and does a mix of cardio (on the elliptical machine, ever since his knees wore out and he had to stop running) and strength training three days a week at a gym near his home in the Boston suburb of Newton." This is a pretty sensible anti-aging regimen. Vitamin D and baby aspirin reduce all-cause mortality in the elderly in the meta-analyses, statins are probably helpful, daily weighing will help avoid obesity and metabolic disorder leading to all sorts of bad things like diabetes, and likewise the cardio & weight training. Such a regimen is probably good for at least 2 additional years of life expectancy. If he was going to add anything more, it would have to be metformin or low-dose rapamycin, and those are speculative enough that one might want to wait for TAME/MILES results before deciding.