With the 1.0.0 release, there are Windows binaries for all supported Python versions (2.7, 3.4, 3.5). Make sure you upgrade to the latest version of Pip before

With the 1.0.0 release, there are Windows binaries for all supported Python versions (2.7, 3.4, 3.5). Make sure you upgrade to the latest version of Pip before trying to pip install grpcio. (The binaries use some ABI tags that are only recognized by newer versions of pip)