The images are 1-5 gb each. They tile them. Then they did some simple sorting (remove all tiles with lots of white), (emphasize tiles with lots of blue), then t

The images are 1-5 gb each. They tile them. Then they did some simple sorting (remove all tiles with lots of white), (emphasize tiles with lots of blue), then they did random forests, survival models and k-fold cross validation. The test set is interesting: they used a completely unrelated dataset of tissue microarray spots. This are tiny, 1-2 mm circles. Whereas the TCGA images are full size tissue cassettes, up to 1" on the short side.