https://wicg.github.io/webusb/ https://wicg.github.io/webusb/ is implemented on Chrome today behind experimental flags. It's not an answer for legacy USB device

https://wicg.github.io/webusb/ https://wicg.github.io/webusb/ is implemented on Chrome today behind experimental flags. It's not an answer for legacy USB devices, but for new devices that take into account the web's same-origin policy, it's quite powerful.