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This was the story with heroin, oxymorphone, codeine... Practically every generation was in theory safer and actually turned out to be much worse.
by 1propionyl 10y ago
This was the story with heroin, oxymorphone, codeine... Practically every generation was in theory safer and actually turned out to be much worse.
- 1propionyl 10y agoI should clarify I'm supposing that by opioid they mean morphine based opioids.
- jcoffland 10y agoYou should probably read the article. It's not morphine based.
- goldenkey 10y agoIt is targeting mu opioid receptors, mentioned in the article as "morphine receptor." It may not contain morphine, chemically, but neither does oxymorphone, it's only similar.. the only drug mentioned that actually contains morphine, ie. is morphine based is heroin. But having side chains and other additions can totally change a drugs' effects. Morphine-based is a poor distinction.
- akiselev 10y agoTurned out to be much worse based on what evidence? All three of your examples have been in use for over a century and there have been dozens of pain killers invented since then that are much better at targeting specific pain receptors without the addiction.