Yes, it affects the NMDA receptors similar to Ketamine, though it's "safer" (when taken properly). Just search for DXM online. You can also read articles posted

Yes, it affects the NMDA receptors similar to Ketamine, though it's "safer" (when taken properly). Just search for DXM online. You can also read articles posted to Erowid. Another alternative is Memantine, but DXM also acts as a sort of SSRI and affects the mu-sigma opioid receptors, so for this one-off-once-every-2-weeks use it's more appropriate. You can also research options like combining it with Phenibut (1-2g split across 2 servings the day and night before, as it can become addictive or problematic if used too often (more than 1-2x/week) or in high quantities (more than 1-2g/day)), 5-HTP, Melatonin, fasoracetam, etc.