It depends how you want to contribute. If you want to offer your services as a programmer to the biology community, there are several open source projects out

It depends how you want to contribute. If you want to offer your services as a programmer to the biology community, there are several open source projects out there to develop LIMS (lab information systems), user friendly interfaces to many common analysis tools, and web portals for various research communities to share biological data. I wouldn't consider any of this to be 'computational biology', however. It's a common misconception that computational biology (or bioinformatics, or whatever you want to call it) = biology + software development. While it's true that the biological research needs more software developers to build the infrastructure necessary to manage and access a growing amount of biological data, that's not the role of computational biologists. The computational biologist is just a biologist who uses computational methods as opposed to traditional laboratory methods. Some may not even write that much code, and the code they do write may not even equate to 'software'. The skill set involves algorithms, statistics, and AI much more than software engineering.