Interestingly, there's one difference between sucrose and a 50:50 glucose/fructose mix: the sucrose will have less sweetness per calorie, because it's only one

Interestingly, there's one difference between sucrose and a 50:50 glucose/fructose mix: the sucrose will have less sweetness per calorie, because it's only one molecule (a disaccharide) and can thus stimulate only half as many sweet receptors. Given that the body attempts to measure current calorie intake by calibrating past calorie consumption versus past perceived sweetness, this means that the glucose/fructose mix will prime the body to crave sweets more intensely. This is pretty much the only biologically plausible argument against HFCS. Compare: the studies showing that diet sodas actually lead to an increased risk of diabetes (doi:10.2337/dc08-1799). Compare: the various diets encouraging the daily consumption of nearly-flavorless olive oil (example implementation, unsuccessful: http://lesswrong.com/lw/a6/the_mysteries_of_shangrila_dieting/ http://lesswrong.com/lw/a6/the_mysteries_of_shangrila_dietin...).