I've been doing so for years. Having spent almost a decade in the ISP industry, I don't trust other providers for anything but transit. I have a 50/10 connect

I've been doing so for years. Having spent almost a decade in the ISP industry, I don't trust other providers for anything but transit. I have a 50/10 connection from Comcast Business with five static IPs. One of those hosts what used to be a colo box with an ISP in Austin (I'd worked for them years ago, and had a services-for-colo agreement that lasted until an ownership change). For about five years now I've had no problems sending or receiving mail; just keep a common-sense best practices configuration and do regular checks to make sure that you're not relaying/sending spam and aren't on any RBLs. "Nux"'s comment is a good list.