A lot of the batteries in Python, and Python itself, is written in C. Perhaps take that as a model/starting point: write the things that you want to be debuggab

A lot of the batteries in Python, and Python itself, is written in C. Perhaps take that as a model/starting point: write the things that you want to be debuggable/whateverable in C (or C++ or Java or ...), and glue them together with Python. It's good enough for Guido.