Semiconductors care a lot. There is a sweet spot in the <= 48V range, and even more in the <= 24V range. High voltage devices are much harder to miniaturize, an

Semiconductors care a lot. There is a sweet spot in the <= 48V range, and even more in the <= 24V range. High voltage devices are much harder to miniaturize, and the conversion ratios for the inevitable logic supplies can be done a lot cheaper at lower voltages. Safety is of course a huge component. 48V is about the limit before special isolation and insulation is required.