Here you go (something I have posted previously on this forum)- 1. Timezone issues - this is, imo, the biggest one. Especially after working with people in Chi

Here you go (something I have posted previously on this forum)- 1. Timezone issues - this is, imo, the biggest one. Especially after working with people in China, India, Europe or even eastern USA (with me in SF bay area). People all over the world usually start working around 9-10, and stop working around 6-7. Meetings, code/design discussions are very difficult on those schedules, especially when you want a decision on smaller issues where a quick back n forth would settle the matter in 30 min if everyone was in the same room. And there are plenty of such issues, where unavailability of your coworkers seriously affects the productivity. 2. Impromptu discussions: These are triggered by spontaneous ideas, and ideas do not come according to a fixed schedule of meetings. By not having remote workers in these discussions, both sides lose (by not having more brains, as well as by missing out).