As far as python is concerned, if you mostly care about code navigation and autocompletion, try jedi-mode, it's fast, leightweight and works pretty well (I've u

As far as python is concerned, if you mostly care about code navigation and autocompletion, try jedi-mode, it's fast, leightweight and works pretty well (I've used it successfully with virtualenv and conda, although the later required me to manually pip install epc-server and jedi and maybe one or two other deps). If you want refactorings, you're out of luck (rope is not even alpha quality, and I don't know of anything else). But firing up your IDE every few days or weeks for a bigger refactoring might be acceptable. Javascript has js2-refactor, but I haven't tried that. Lastly, instead of having 5-7 IDEs you could just get an Intellij license – it can basically do all that more specialized offerings like Webstorm and Pycharm can, and it's unlikely you'll ever have similar semantic support in a plain editor. I'm currently using emacs exclusively myself, but have also used products of the intellij family extensively, and might do so again depending on the project. The javascript livecoding and mixed-language-fragment support is pretty neat for example.