I assume that you'd first need a native JS TUF package published to NPM. I don't think that adding another language dependency is a decision that would be taken

I assume that you'd first need a native JS TUF package published to NPM. I don't think that adding another language dependency is a decision that would be taken lightly. Additionally, I don't see any Windows instructions (NB: python-ffi) and Node supports Windows as a first-class citizen.