Maybe the cloud computer guys will go there, but the high performance computing people are already well settled. Anton [1], a machine running custom ASICs for m

Maybe the cloud computer guys will go there, but the high performance computing people are already well settled. Anton [1], a machine running custom ASICs for molecular dynamics, has already produced some very interesting biomolecular simulations. MDGRAPE3 was even earlier (completed in 2006). There was also a (sadly failed) initiative about ten years back in Germany to build a custom ASIC for multigrid Poisson equation solvers. I'm sure there are more examples outside of my interests. [1] https://en.m.wikipedia.org/wiki/Anton_(computer) https://en.m.wikipedia.org/wiki/Anton_(computer)