I was thinking about spam resistant mail. Maybe one day I will do this as a service. It's greatest strength is also major inconvenience. So I hope it would work

I was thinking about spam resistant mail. Maybe one day I will do this as a service. It's greatest strength is also major inconvenience. So I hope it would work not only for technical minded. Probably it could be dealt with by having good UX/UI. Basically the point is to give every interested party separate address to write to. Giving user a button to generate new random address (120-160bit random number encoded with Crockford's Base32). A bit like user+whatever@gmail.com that gmail supports, but my idea can't be easily gamed by not having constant part (like user@gmail.com). User can register to various services with different address and can detect when his email address was compromised. Inconveniences: giving address to friends, writing them down on paper forms, dictation via phone. Maybe it would be a bit like having multiple telephone numbers - separate for every one. For leaving out address for random people like on mailing lists or blog posts, there could be additional step of sending introductory e-mail with certain subject prefix required that would work a bit like CAPTCHA. Than you could reply from new address - designated for this person.