That's tough to do if the application in question is a script engine or is merely script-enabled like Excel or Word. One ad-hoc thing you could do to beat some

That's tough to do if the application in question is a script engine or is merely script-enabled like Excel or Word. One ad-hoc thing you could do to beat some of the ransomware out there is remove or break things like vssadmin.exe so the ransomware can't prevent you from reverting to a previous version of a file. I don't know if mac has something analogous to this, though.