As to your first question I am not sure what you define as 'novel state', I am assuming you do not mean in the form of and LSD trip. But if you could clarify I

As to your first question I am not sure what you define as 'novel state', I am assuming you do not mean in the form of and LSD trip. But if you could clarify I could attempt to address your question. An interesting example would be the treatment of migraines, and or focal epilepsy using TMS. Migraine treatment with TMS, is believed to set the brain in a controlled firing rhythm, whereas migraines are believed to be caused by uncoordinated neural firing similar to epilepsy but in a milder form. Recently the FDA has approved such a treatment: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm378608.htm http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/uc...