My experience says, flask is a better choice, if you anticipate lots of changes in tech needs(like, async webservers, heavy UX customization in workflow etc.

My experience says, flask is a better choice, if you anticipate lots of changes in tech needs(like, async webservers, heavy UX customization in workflow etc....) then flask (or other micro web-frameworks) are useful. If not you can go with django and build the rest around it. However, django over the recent years have been making an effort to make their stuff more plug-and-play style..