Not sure why you say HDL has no effect. Ratios of "bad" to "good" markers have been shown to be much better predictors of risk than any one number on its own, e

Not sure why you say HDL has no effect. Ratios of "bad" to "good" markers have been shown to be much better predictors of risk than any one number on its own, even LDL. https://www.youtube.com/watch?v=YRFRRqe0vrE&t=924s https://www.youtube.com/watch?v=YRFRRqe0vrE&t=924s You should also take a look at the latest risk calculator derived from the Framingham Heart Study. It's basically a multivariate regression of various risk factors against CVD risk. Total cholesterol and HDL are inputs, while trigs and LDL aren't used. They do of course factor into total cholesterol, but the researchers specifically stated that "The use of low-density lipoprotein cholesterol did not improve model fit or performance." http://circ.ahajournals.org/content/117/6/743.long http://circ.ahajournals.org/content/117/6/743.long