Has anyone tried combining fuzzing with 'all-pairs'/'pairwise' test case generation? The idea of pairwise testing is that individual features in a program are

Has anyone tried combining fuzzing with 'all-pairs'/'pairwise' test case generation? The idea of pairwise testing is that individual features in a program are commonly tested, but combinations of them are often poorly tested. However, trying to test all features with each other soon becomes a combinatorial nightmare. To deal with this, you use an algorithm (e.g. see the code for 'allpairs' at http://www.satisfice.com/tools.shtml http://www.satisfice.com/tools.shtml ) to pick a minimal set of test cases that cover all possible pairs of configuration settings. These test cases could then be used as starting points for fuzzing, to provide a greater code coverage faster.