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> Given that the US is a lot more racially heterogenous The US? Sure, but this isn't about the US. The population chosen (or available) for the study does no

> Given that the US is a lot more racially heterogenous The US? Sure, but this isn't about the US. The population chosen (or available) for the study does not reflect that diversity. https://www.framinghamheartstudy.org/participants/index.php https://www.framinghamheartstudy.org/participants/index.php > The Original Cohort of the Framingham Heart Study consisted of 5,209 respondents > of a random sample of 2/3 of the adult population of Framingham, Massachusetts So I don't understand why you point to diversity in some wider but not included group to reason about results based on the much more limited one. Stratification doesn't help much - it doesn't generate missing data, it still is based on that limited population. The study isn't "wrong" of course, it clearly states what data it is based on and what methods they employed. If there's anything wrong it's the interpretation by others. This is merely a hint "maybe worth having a closer look at this", it isn't meant to be used to draw any final conclusions from. Papers like this are for "internal use", for other researchers in the field, it should never go to the wider media. It's like a programmer showing their very first lines of code for a new idea, and then trying to draw conclusions about the quality of the final software to be released five years later, written by different people in a different programming language. Bad example, because here at least you already know what it will be about while in the study this remains open, so I reframed it to be about "(software) quality".

Manishearth 10y ago
I used to live in Malden, and IIRC Framingham and the other suburbs were pretty diverse. That's what I was basing my comment on. Of course, my personal bubble could have skewed this -- looking it up it seems like Malden is more diverse than Framingham, but Framingham seems to still be close enough to the overall distribution in the US. Not the same of course. shrug > The study isn't "wrong" of course, it clearly states what data it is based on and what methods they employed. If there's anything wrong it's the interpretation by others. This is merely a hint "maybe worth having a closer look at this" Right, that's all I'm really talking about -- the paper is very responsible about possible bias, and tries to correct it (as you said, that's not completely possible), very far from "I can't believe this got published" territory as the original commenter was mentioning.
- Noseshine 10y ago
  Okay, here is what you wrote: > Given that the US is a lot more racially heterogenous than the majority of the world "The US". You didn't say "Framingham". You know, it's really a PITA to have discussions with someone who can't just say "I made a mistake, I edited my comment" or something like that and instead try anything else.
  - Manishearth 10y ago
    Sure, I made a mistake. I was using prior knowledge of Framingham/the region that I didn't spell out in my first comment. I should have done that, but I was lazy and it didn't occur to me. Happy? I spelled it out in the next comment to explain the basis of the previous one, which I felt was sufficient. Evidently it wasn't; because you want explicit admission of fault. Here you go.

Manishearth 10y ago

I used to live in Malden, and IIRC Framingham and the other suburbs were pretty diverse. That's what I was basing my comment on. Of course, my personal bubble could have skewed this -- looking it up it seems like Malden is more diverse than Framingham, but Framingham seems to still be close enough to the overall distribution in the US. Not the same of course. shrug > The study isn't "wrong" of course, it clearly states what data it is based on and what methods they employed. If there's anything wrong it's the interpretation by others. This is merely a hint "maybe worth having a closer look at this" Right, that's all I'm really talking about -- the paper is very responsible about possible bias, and tries to correct it (as you said, that's not completely possible), very far from "I can't believe this got published" territory as the original commenter was mentioning.

Noseshine 10y ago
Okay, here is what you wrote: > Given that the US is a lot more racially heterogenous than the majority of the world "The US". You didn't say "Framingham". You know, it's really a PITA to have discussions with someone who can't just say "I made a mistake, I edited my comment" or something like that and instead try anything else.
- Manishearth 10y ago
  Sure, I made a mistake. I was using prior knowledge of Framingham/the region that I didn't spell out in my first comment. I should have done that, but I was lazy and it didn't occur to me. Happy? I spelled it out in the next comment to explain the basis of the previous one, which I felt was sufficient. Evidently it wasn't; because you want explicit admission of fault. Here you go.