You keep making statements referring to _me_ that are inaccurate, but would be correct if you scoped them to "the average consumer" or "an untrained individual.

You keep making statements referring to _me_ that are inaccurate, but would be correct if you scoped them to "the average consumer" or "an untrained individual." First, I've got more than enough biology training to interpret it - a bachelors + a small amount of graduate study looking at analysis of chip-based genetic and protein assays. (Not my day job. I certainly wouldn't claim to be qualified to do this for anyone else.) Second, I certainly do have high confidence that the results are mine. That's actually one of the cool things about a larger assay: I spotted a second cousin in the ancestry components of the list, and the maternal components match exactly with what I know. The remaining issue is simply knowing what their false positive & negative rate is on the carrier status reports. I don't know, but given that we have a pretty good prior that I wasn't likely to be a carrier, it was sufficient for our purposes. (And, in fairness to 23andme, that's one part the FDA is letting them continue to provide.) All of the concerns you've expressed make sense in general. I absolutely wouldn't encourage anyone to do this without talking to their doctor.