Details, details, details. https://www.researchgate.net/profile/Daniel_Epner/publication/11049822_Nutrient_Intake_and_Nutritional_Indexes_in_Adults_With_Metast

Details, details, details. https://www.researchgate.net/profile/Daniel_Epner/publication/11049822_Nutrient_Intake_and_Nutritional_Indexes_in_Adults_With_Metastatic_Cancer_on_a_Phase_I_Clinical_Trial_of_Dietary_Methionine_Restriction/links/53f1f55b0cf272810e4c7a1a.pdf https://www.researchgate.net/profile/Daniel_Epner/publicatio... > Alternatively, weight loss experienced by patients in the trial may have been independ - ent of energy intake but, rather, attributable to “obligatory” muscle catabolism related to methionine restriction per se. A recent study designed to quantify dietary methionine re - quirements in normal subjects sheds light on this issue (22). In that study, stable isotope methods were used to measure obligatory methionine oxidation in normal subjects on a diet completely devoid of sulfur amino acids (methionine and cysteine) for 5 days. Although somewhat controversial (23), obligatory oxidation rates are considered by many to repre - sent the minimum requirement for amino acids, that is, the amount that is oxidized despite maximal body conservation. The obligatory oxidative loss of methionine was 13 mg/kg/ day in that study (22). Patients in our trial, who were re - stricted to 2 mg methionine/kg/day, therefore, consumed 11 mg/kg/day less than the minimum requirement. However, they consumed adequate amounts of cysteine, which is pres - ent in Hominex-2. They therefore may have had obligatory methionine oxidation rates < 13 mg/kg/day. The fact that all patients reversibly lost weight, despite what would normally be considered adequate energy and protein intake, may actu - ally be encouraging, since it confirms that patients adhered to the diet. The basic premise of this strategy is that dietary methionine restriction will have a greater deleterious effect on tumors than on normal host tissues. Unless you actually have cancer, obligate muscle catabolism secondary to methionine restriction is a high price to pay.