4 ms·

A new study finds that mice with genes from three parents live longer

14 points by llovan 10y ago

scotty79 10y ago
I'd like to see some cross-species mitochondrial donation. I'd bet mouse with bat mitochondria would live for decades and never get cancer. (Some telomerase might be necessary too)
- TheSpiceIsLife 10y ago
  I'm keen for designer pets. I'd like a dog with a bit of cat and cow mixed in, so I could let it roam free and know it will always come home, maybe a bit of elephant for longevity.
  - scotty79 10y ago
    Mice is obviously just the first step. When mitochondrial wrangling is perfected I'd like my (yet unborn) grandchildren to get some bat mitochondria. Bats must had their mitochondria selected for amazing performance and reliability. Using those could eliminate all those pesky old age diseases caused by "leaking" mitochondria.
    - TheSpiceIsLife 10y ago
      I know I could go a searching, but one of the things I really like about HN is asking and seeing the bespoke responses. So, what's so special about bat mitochondria?
      - scotty79 10y ago
        Usually animals that have faster metabolic rate have shorter lifespans. It's theorized that this might be because mitochondria get damaged as they provide energy for the cells. Eventually they start leaking free radicals and destroying the cell. Flying creatures are exception. For flight animal needs extreme amounts of energy so in theory bats should have livespan shorter than mice but that's not the case. Somehow bats manage to pass huge amounts of energy during their lifetime and still have pretty decent livespan. Evolution can figure out workarounds for even most fundamental problems if there's proper motivation. Some people think that aging and cancer are just result of evolution sloppiness cause by the lack of need for cancer-free, living longer than necessary individuals. https://en.wikipedia.org/wiki/Rate-of-living_theory https://en.wikipedia.org/wiki/Rate-of-living_theory https://en.wikipedia.org/wiki/Mitochondrion#Possible_relationships_to_aging https://en.wikipedia.org/wiki/Mitochondrion#Possible_relatio... There's another clue that mitochondria age and get worse as they work and and are very important. All of our mitochondria come from female reproductive cell. Mitochondria from male reproductive cells are discarded, possibly because they degraded when male reproductive cell traveled meet to female reproductive cell. Female reproductive cell is inert and created very early in life and stored throughout lifetime to provide untarnished mitochondria to offspring. Male reproductive cells are created throughout life of an individual, but they get gradually less mobile when they were made by older individual. It's possible that this loss of mobility is caused by damage that mitochondria sustained during male lifetime. I can recommend https://www.amazon.com/Oxygen-Molecule-World-Popular-Science/dp/0198607830 https://www.amazon.com/Oxygen-Molecule-World-Popular-Science... It's bit speculative towards the end but makes many very interesting points. Written by Nick Lane, Professor of Evolutionary Biochemistry in the Department of Genetics, Evolution and Environment at University College London Another clue that mitochondria have costant damaging effect on cells probably increasing in intensity with aging http://www.medicalnewstoday.com/articles/306179.php http://www.medicalnewstoday.com/articles/306179.php
- ra1n85 10y ago
  I wish we could put a whimsical and fun spin on GMOs as well. Feed the planet with fewer chemicals and in harsher conditions? Boring. A corn hybrid spliced with 3 Hour Energy Supplement*, guaranteed to give you the step to the next level in everything you do (TM). Ship it.
sushid 10y ago
Click the first link from this search to get around the paywall. https://www.google.com/search?q=A+new+study+finds+that+mice+with+genes+from+three+parents+live+longer https://www.google.com/search?q=A+new+study+finds+that+mice+...

14 points by llovan 10y ago

I'd like to see some cross-species mitochondrial donation. I'd bet mouse with bat mitochondria would live for decades and never get cancer. (Some telomerase might be necessary too)

TheSpiceIsLife 10y ago
I'm keen for designer pets. I'd like a dog with a bit of cat and cow mixed in, so I could let it roam free and know it will always come home, maybe a bit of elephant for longevity.
- scotty79 10y ago
  Mice is obviously just the first step. When mitochondrial wrangling is perfected I'd like my (yet unborn) grandchildren to get some bat mitochondria. Bats must had their mitochondria selected for amazing performance and reliability. Using those could eliminate all those pesky old age diseases caused by "leaking" mitochondria.
  - TheSpiceIsLife 10y ago
    I know I could go a searching, but one of the things I really like about HN is asking and seeing the bespoke responses. So, what's so special about bat mitochondria?
    - scotty79 10y ago
      Usually animals that have faster metabolic rate have shorter lifespans. It's theorized that this might be because mitochondria get damaged as they provide energy for the cells. Eventually they start leaking free radicals and destroying the cell. Flying creatures are exception. For flight animal needs extreme amounts of energy so in theory bats should have livespan shorter than mice but that's not the case. Somehow bats manage to pass huge amounts of energy during their lifetime and still have pretty decent livespan. Evolution can figure out workarounds for even most fundamental problems if there's proper motivation. Some people think that aging and cancer are just result of evolution sloppiness cause by the lack of need for cancer-free, living longer than necessary individuals. https://en.wikipedia.org/wiki/Rate-of-living_theory https://en.wikipedia.org/wiki/Rate-of-living_theory https://en.wikipedia.org/wiki/Mitochondrion#Possible_relationships_to_aging https://en.wikipedia.org/wiki/Mitochondrion#Possible_relatio... There's another clue that mitochondria age and get worse as they work and and are very important. All of our mitochondria come from female reproductive cell. Mitochondria from male reproductive cells are discarded, possibly because they degraded when male reproductive cell traveled meet to female reproductive cell. Female reproductive cell is inert and created very early in life and stored throughout lifetime to provide untarnished mitochondria to offspring. Male reproductive cells are created throughout life of an individual, but they get gradually less mobile when they were made by older individual. It's possible that this loss of mobility is caused by damage that mitochondria sustained during male lifetime. I can recommend https://www.amazon.com/Oxygen-Molecule-World-Popular-Science/dp/0198607830 https://www.amazon.com/Oxygen-Molecule-World-Popular-Science... It's bit speculative towards the end but makes many very interesting points. Written by Nick Lane, Professor of Evolutionary Biochemistry in the Department of Genetics, Evolution and Environment at University College London Another clue that mitochondria have costant damaging effect on cells probably increasing in intensity with aging http://www.medicalnewstoday.com/articles/306179.php http://www.medicalnewstoday.com/articles/306179.php
ra1n85 10y ago
I wish we could put a whimsical and fun spin on GMOs as well. Feed the planet with fewer chemicals and in harsher conditions? Boring. A corn hybrid spliced with 3 Hour Energy Supplement*, guaranteed to give you the step to the next level in everything you do (TM). Ship it.

sushid 10y ago

Click the first link from this search to get around the paywall. https://www.google.com/search?q=A+new+study+finds+that+mice+with+genes+from+three+parents+live+longer https://www.google.com/search?q=A+new+study+finds+that+mice+...