4 ms·
Chemical antibiotics are currently the best and most developed tool we have for bacterial infection, but other options are being explored, including defensins[1
by tomkinstinch 10y ago
Chemical antibiotics are currently the best and most developed tool we have for bacterial infection, but other options are being explored, including defensins[1,2,3] (antimicrobial peptides) and—as mentioned in the article—phage therapy[4,5,6,7] (viruses that infect and replicate within a bacterium). Like many of our current antibiotics, they have their origins in nature. As therapeutics, they're far off, and would have to be characterized and go through the usual clinical trial process to be evaluated for efficacy and safety. Specificity is an issue for phages, and delivery is a challenges for both. One novel application is a defensin-based chewing gum being developed by the US military to combat the bacteria responsible for dental plaque[8,9].
1. http://www.nature.com/nri/journal/v3/n9/full/nri1180.html http://www.nature.com/nri/journal/v3/n9/full/nri1180.html
2. https://en.wikipedia.org/wiki/Defensin https://en.wikipedia.org/wiki/Defensin
3. http://onlinelibrary.wiley.com/doi/10.1002/biot.200700148/abstract;jsessionid=502B8ABC8A1924B726025B62168619BE.f03t01 http://onlinelibrary.wiley.com/doi/10.1002/biot.200700148/ab...
4. http://www.nature.com/news/phage-therapy-gets-revitalized-1.15348 http://www.nature.com/news/phage-therapy-gets-revitalized-1....
5. https://www.amazon.com/Forgotten-Cure-Future-Phage-Therapy/dp/1461402506 https://www.amazon.com/Forgotten-Cure-Future-Phage-Therapy/d...
7. https://en.wikipedia.org/wiki/Phage_therapy https://en.wikipedia.org/wiki/Phage_therapy
8. http://www.newyorker.com/tech/elements/zero-dark-cavity http://www.newyorker.com/tech/elements/zero-dark-cavity
9. http://www.usaisr.amedd.army.mil/news/news_stories/2014_FEB/DTRD_developing_anti_plaque_chewing_gum.html http://www.usaisr.amedd.army.mil/news/news_stories/2014_FEB/...
- Retric 10y agoPhages are not universal in nature like Antibiotics which limits their value.
- Fomite 10y agoAs much as I love phage therapy (and have loved it for more than a decade now), it's miles away from being as useful as antibiotics, or as functional.
- dredmorbius 10y agoI just want to say thank you for a hugely informative, referenced, and brief comment. You've pointed me at more information on a concept I'm familiar with (bacteriophages), and taught me two new terms -- defensins and antimicrobial peptides. Clipped & saved.