3 ms·
A misleading headline for a diagnostic test with moderate sensitivity and unstated specificity. I desperately want to believe that chronic fatigue syndrome is
by zanchey 10y ago
A misleading headline for a diagnostic test with moderate sensitivity and unstated specificity.
I desperately want to believe that chronic fatigue syndrome is as simple as a microbiological imbalance and I hope that we can see some stronger proof but this is an illness that has foxed us for a long time.
From UpToDate, my current preferred summary resource (https://www.uptodate.com/contents/clinical-features-and-diagnosis-of-systemic-exertion-intolerance-disease-chronic-fatigue-syndrome https://www.uptodate.com/contents/clinical-features-and-diag... but extortionate subscription required, sorry):
"The proposed diagnosis was chronic brucellosis from the 1930s to the 1950s and hypoglycemia from the 1950s to the 1970s. Other hypotheses have included chronic Epstein-Barr virus (EBV) infection [11-13], purported chronic Lyme disease, total allergy syndrome, multiple chemical sensitivity syndrome [14], chronic candidiasis [15], and xenotropic murine leukemia virus-related virus (XMRV) and related retroviruses, such as murine leukemia virus (MLV) [16,17]. None of these etiologic agents have been scientifically linked to the SEID/CFS."
Extraordinary claims require extraordinary evidence.
- greenyoda 10y agoAlso, the article says: "The researchers have no evidence to distinguish whether the altered gut microbiome is a cause or a whether it is a consequence of disease". If the altered gut microbiome is a consequence rather than a cause, the cause isn't necessarily even in the gut.