I think in some fields achieving (c) is almost impossible - the n number needed would be too expensive for most labs working with animal models, for instance.

I think in some fields achieving (c) is almost impossible - the n number needed would be too expensive for most labs working with animal models, for instance. (b) would be interesting, especially if it led to a culture where "failed" results are still worth publishing because they disprove something. I think (a) is the one worth focusing on first, since that seems the most achievable and would let you back-apply some of the other improvements at a later date.