One problem is that it requires about 33% more glucose to match the sweetness of sucrose and 126% more glucose to match the sweetness of fructose. Glucose has a

One problem is that it requires about 33% more glucose to match the sweetness of sucrose and 126% more glucose to match the sweetness of fructose. Glucose has a much higher effect on insulin levels and glycemic load which makes it a harder problem for diabetics. Fructose, on the other hand, has all the issues described in the Dr. Lustig video linked in another reply. I just avoid anything with a lot of any type of sugar (more than a few grams per serving) as much as I can.