Message passing (and by extension Smalltalk/Squeak) suffers from LISP disease, the notion that because the system makes no constraints on program structure, it

Message passing (and by extension Smalltalk/Squeak) suffers from LISP disease, the notion that because the system makes no constraints on program structure, it can do anything, and therefore is maximally powerful. But "can do anything" is different from "does anything". In real programs you have to solve performance, security, evolving product features needs, a growing team of contributors , static analysis tools to make global changes to the axioms of the system, all those details that matter when software leaves the lab and enters industry.