no, it is a consensus sequence determined by sequencing the genomes of several individuals. i do not know how many individuals were sequenced for hg38, but hg37

no, it is a consensus sequence determined by sequencing the genomes of several individuals. i do not know how many individuals were sequenced for hg38, but hg37 was derived from 13 individuals according to [1]. genomic regions with higher variability between individuals are annotated separately and are not represented in the main chromosomal sequence, but can be aligned to it as such. [1] https://en.wikipedia.org/wiki/Reference_genome https://en.wikipedia.org/wiki/Reference_genome