For B6, 46mg by 10am isn't very much. Most B6 supplements come in 100mg capsules. The FNB noted that although several reports show sensory neuropathy occurring

For B6, 46mg by 10am isn't very much. Most B6 supplements come in 100mg capsules. The FNB noted that although several reports show sensory neuropathy occurring at doses lower than 500 mg/day, studies in patients treated with vitamin B6 (average dose of 200 mg/day) for up to 5 years found no evidence of this effect. Based on limitations in the data on potential harms from long-term use, the FNB halved the dose used in these studies to establish a UL of 100 mg/day for adults. https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/ https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfession...