The latter case has worked out great for us at helme.io. Our computational forecast library is written in Clojurescipt, while the rest of the application is in

The latter case has worked out great for us at helme.io. Our computational forecast library is written in Clojurescipt, while the rest of the application is in JS + Angular. A word of warning: with Clojurescript, at least, there is a big cost to converting between JS and CLJS types. This has been a big painpoint as our need for frequent calculations increases. Still, we wouldn't have it any other way.