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S-Ketamine injected through the ear drum, into the middle ear, is currently undergoing phase III trials as a treatment for noise or infection induced tinnitus.

S-Ketamine injected through the ear drum, into the middle ear, is currently undergoing phase III trials as a treatment for noise or infection induced tinnitus. Chronic tinnitus is currently a condition which if one were to go to the doctor and ask for a cure one would be told to get used to it as there is not much that can be done. The pace of medical and biotech advancement is increasing as the FDA has relaxed a bit and better understanding of human biology is creating cures for what once were incurable diseases. Exciting times, but not fast enough for me. The most interesting question for me these days: How can we 10x the number of dollars and scientists engaged in medical research, and then 10x that?

ycosynot 10y ago
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obiefernandez 10y ago
Dammit, I got my hopes up... :( "The treatment, delivered directly into the inner ear via three injections over three days, must catch the disorder while the problem is still within the ear, before the brain has begun overcompensating for the loss of hearing. Once that happens, no amount of adjustment to the receptors on the auditory nerves will do any good. Because it is not known when that transition from ear to brain occurs, one of the current trials, of 300 European patients, is specifically testing tinnitus sufferers who have developed the condition no more than three months prior to treatment. The other, a study of 330 North American patients, is investigating a therapy within one year post-trauma. Preliminary results suggest that S-ketamine is effective beyond three months, but declines in effectiveness within a year of the initial trauma, so later stages of the trial are being refocused on the four- to six-month time frame. The trials will be completed at the end of this year, and Auris hopes to submit to the US Food and Drug Administration (FDA) for approval in the summer of 2016."

ycosynot 10y ago

Connecting the whole world to internet brings the best returns.

obiefernandez 10y ago

Dammit, I got my hopes up... :( "The treatment, delivered directly into the inner ear via three injections over three days, must catch the disorder while the problem is still within the ear, before the brain has begun overcompensating for the loss of hearing. Once that happens, no amount of adjustment to the receptors on the auditory nerves will do any good. Because it is not known when that transition from ear to brain occurs, one of the current trials, of 300 European patients, is specifically testing tinnitus sufferers who have developed the condition no more than three months prior to treatment. The other, a study of 330 North American patients, is investigating a therapy within one year post-trauma. Preliminary results suggest that S-ketamine is effective beyond three months, but declines in effectiveness within a year of the initial trauma, so later stages of the trial are being refocused on the four- to six-month time frame. The trials will be completed at the end of this year, and Auris hopes to submit to the US Food and Drug Administration (FDA) for approval in the summer of 2016."