I absolutely do, daily, with a 24/7 irssi instance running in screen on a VPS I can connect to from anywhere, but I don't frequent any popular channels or serve

I absolutely do, daily, with a 24/7 irssi instance running in screen on a VPS I can connect to from anywhere, but I don't frequent any popular channels or servers, just smaller ones with channels that are mostly small groups of friends who have known each other for 15 years rather than general purpose channels with a stream of new people.