The level of expression of p53 is quite strongly regulated in human cells and over expression (due to an increase in the copy number) will be lethal. With crisp

The level of expression of p53 is quite strongly regulated in human cells and over expression (due to an increase in the copy number) will be lethal. With crispr/CAS9 it should be possible to do some really interesting experiments in mice to see if increasing the copy number (in a control way) reduces the rate of cancer in mice.