Actually, I don't think many will. For the ipad, if you don't explicitly support the larger layout, you just get a smaller app in the middle of the screen that

Actually, I don't think many will. For the ipad, if you don't explicitly support the larger layout, you just get a smaller app in the middle of the screen that's still picture perfect. And for IB, if you chose to target the iPad itself, you can just make a second XIB file that has your iPad layout for each screen, then load them up depending on hardware. It will be slightly more work, but it will still be backed by the GUI tool, and it will still be pretty easy. You aren't forced into layout manager. As far as iPodTouch iPhone differences, those are really small for the perspective of most apps, or are total deal breakers. Either way, you're usually not doing much accommodation.