All 3 are incredibly hard to parse (well actually I don't know about Appleseed but Blame! and the GiTS manga are difficult to follow). As a huge fan of GiTs SA

All 3 are incredibly hard to parse (well actually I don't know about Appleseed but Blame! and the GiTS manga are difficult to follow). As a huge fan of GiTs SAC / Arise and the original movie, I tried reading the manga but gave up as I felt it was too much work trying to unravel the intricate plot line. So if I were to start somebody off the series I'd recommend watching either the shows or movies first.