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This is a bit silly, eh. Every cell in your body does this kind of epigenetic modification, there are a whole host of factors whose only job is to methylate DNA
by astazangasta 10y ago
This is a bit silly, eh. Every cell in your body does this kind of epigenetic modification, there are a whole host of factors whose only job is to methylate DNA. Furthermore, this is not really "altering DNA", the sequence doesn't change, this is just a way to mask gene expression - if you methylate cytosines near the promoter region of a gene, RNA polymerase has a harder time sitting down and transcribing the gene, reducing its expression.
Neurons do this, germ cells do this, immune cells do this, every cell in the body does this.
What's interesting here is the specific factor (Tet3), not the occurrence of epigenetic modification. The perils of science journalism, as usual.
- nickledave 10y agoExactly. I should know better and I got caught up in the excitement of "neurons editing their DNA". The Hopkins press release department was either clueless or trying to make this paper sexier than necessary. The Tet3 finding is cool; Wonder if that factor does the same thing in other cells besides neurons, or if really just responds to synaptic activity.